Pokerstars Hotkeys not working while PT4 is running

[Flag_Hippo]

I tried doing that and then running C:\Program Files (x86)\PokerStars\PokerStars.exe but it's still not working

I cannot reproduce this when running PokerStars.exe as administrator. Please open a Support Ticket and let us know what PokerStars client you are using via 'Help -> About Poker Stars -> Client Version'.